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Breast Cancer News

In this section, access cutting-edge metastatic breast cancer news on treatment updates, emerging therapies, study results and other medical and quality-of-life issues important to you.

Neratinib Plus Capecitabine Shows Promise in HER2-Positive Metastatic Breast Cancer Study

A small, stage I/II study found that giving the anti-cancer medicines neratinib and capecitabine at the same time may help people with HER2-positive metastatic breast cancer that is no longer responding to standard treatment.

FDA Grants Accelerated Approval of Palbociclib

Pfizer, a company that makes and sells medicine, announced Feb. 3 that the U.S. Food and Drug Administration (FDA) granted accelerated approval of its anticancer medicine, palbociclib (Ibrance) – in combination with letrozole (Femara) – for postmenopausal women with estrogen receptor-positive, HER2-negative metastatic breast cancer.

Updates from San Antonio Breast Cancer Symposium

Highlights from the annual San Antonio Breast Cancer Symposium held December 9-13, 2014 including presentation of results from a new survey conducted by Living Beyond Breast Cancer on the psychosocial needs of women with triple-negative breast cancer. 

Study: Severe Side Effects Uncommon After Taking T-DM1

After looking at information from seven studies involving T-DM1 (Kadcyla), researchers found that severe side effects were uncommon. If they did occur, they were usually manageable.

ASCO Issues Guideline for Metastatic HER2-negative Breast Cancer

The American Society of Clinical Oncology, ASCO, released a new treatment guideline for HER2-negative breast cancer that has spread from the breast to nearby areas or distant parts of the body.

Final Results of TH3RESA Trial Confirm Effectiveness of T-DM1

Final results of the phase III TH3RESA trial confirm that the medicine T-DM1 extends progression-free survival, PFS, in people who have HER2-positive metastatic breast cancer that no longer responds well to first-line treatments, such as trastuzumab. PFS is the time from the start of treatment until the disease grows or spreads.

Early results of this study were presented at the European Cancer Congress, in Amsterdam, in the fall of 2013.

CLEOPATRA Final Results: Perjeta Extends Life Significantly

Final results from the CLEOPATRA trial were presented at the European Society for Medical Oncology (ESMO) 2014 Congress in Madrid at the end of September. The results show the combination of trastuzumab and pertuzumab, along with chemotherapy, lengthened the lives of women with HER2-positive metastatic breast cancer by a median 15.7 months. The increase is being called unprecedented.

Research May Mean Fewer Side Effects For Women With Bone Metastases

New findings may pave the way for people with stage IV breast cancer in the bones to receive bone-strengthening treatment less often. These results could mean decreased risk of side effects.

ASCO Issues First Guidelines for Metastatic HER2-positive Breast Cancer

To help doctors recommend treatment options based on research evidence and expert consensus, the American Society of Clinical Oncology released its first guidelines on treating metastatic HER2-positive breast cancer.

ASCO issued two clinical practice guidelines for this breast cancer type. One advises on systemic (whole body) therapies for HER2-positive breast cancer that has advanced outside of the breast, other than to the brain. The other recommends specifics on treating brain metastases.

Everolimus Plus Exemestane — A Possible First-Line Therapy for Metastatic Disease

Everolimus (Afinitor) and exemestane (Aromasin) taken at the same time may be an effective first-line treatment for hormone receptor-positive breast cancer that spread beyond the breast to other organs, after treatment with another aromatase inhibitor. This finding comes from a new analysis of data from the BOLERO-2 trial.