Ribociclib

Updated 
September 20, 2017

Ribociclib (Kisqali), a targeted therapyinfo-icon, is the second CDK 4/6 inhibitor to be approved by the FDAinfo-icon. It targets two specific kinases, or enzymes, that help tumorinfo-icon cells grow and divide.

How Ribociclib Works

Cyclin-dependent kinase 4 and 6 are two enzymes that help tumorinfo-icon cells grow and multiply. By blocking the action of CDK 4 and 6, ribociclib interferes with signals that tell cancer cells to quickly reproduce.  This helps slow or even stop the growth or spread of cancer cells.

How Ribociclib Is Given

Ribociclib is a pill. It is usually taken once a day for the first 21 days of a 28-day cycle. The pill can be taken with or without food, and should be taken at the same time each day, preferably in the morning.

It is given with an aromatase inhibitorinfo-icon, which is also a pill. The aromatase inhibitor should also be taken once a day, at the same time each day, preferably in the morning. It is taken for all 28 days of the cycle.

You and your doctor will discuss how many times you should repeat this cycle.

Ribociclib can be paired with any aromatase inhibitor. But if your doctor recommends letrozoleinfo-icon (Femarainfo-icon), a 28-day supply of the medicines can be sold together. This is called a Kisqali Femara Co-Pack. It requires one copay rather than two, and costs the same as ribociclib alone, according to Novartis, the company that makes both medicines.

Side Effects and Things to Remember

The most common side effects of riboclicib are listed below.

About 50 percent of people who take ribociclib experience nausea.

Between 30 and 40 percent of people who take ribociclib have the following side effects:

Between 20 and 30 percent of people who take ribociclib have the following side effects:

  • Vomiting
  • Constipation
  • Headache
  • Back pain

Three out of four people who take ribociclib experience neutropenia and one out of three experience leukopeniainfo-icon, low white blood cellinfo-icon counts. These side effects, when caused by chemotherapyinfo-icon, often increases risk of infectioninfo-icon. When caused by ribociclib, that does not appear to happen.

An irregular heartbeat is an uncommon but serious possible side effectinfo-icon of ribociclib. Your doctor will run tests on your heart before and during treatment with ribociclib.

These are not all the possible side effects of ribociclib. More can be found here.

Before starting ribociclib, be sure to tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over the counter medicines. Also tell your doctor if you have ever had heart or liver problems. You should avoid grapefruit and pomegranate, as well as their juices, while you are taking this medicineinfo-icon.

You should avoid becoming pregnant, and breastfeeding, while you are taking ribociclib and for at least 3 weeks after taking the last doseinfo-icon. Tell your doctor right away if you become pregnant or may be pregnant while you are undergoing treatment.

Your doctor, pharmacistinfo-icon or nurseinfo-icon can help you manage your side effects. You can also go to our section on Side Effects for more information.

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