Nicole Simone, MD

Nicole Simone, MD is a radiation oncologist, the Margaret Q. Landenberger Professor of Radiation Oncology, co-leader of the Breast Cancer Research Program at the Sidney Kimmel Cancer Center at Jefferson, and radiation director for the Jefferson Breast Care Center in Philadelphia.

Prior to her work at Jefferson, Dr. Simone was on staff at the National Cancer Institute, where she looked at the long-term toxicity caused by cancer treatment. She then accepted a physician-scientist position at Thomas Jefferson University in Philadelphia. Her research focuses on how caloric restriction, or a reduction in overall calories, can increase the response of chemotherapy and radiation therapy in cancers such as breast and prostate cancer. She has shown that caloric restriction, combined with radiation, inhibits both tumor growth and metastasis and improves survival in both breast cancer and prostate cancer.

Dr. Simone currently has three open clinical trials using diet for breast cancer, prostate cancer and endometrial cancer (cancer of the lining of the uterus). She has authored over 40 research publications, and sits on many national grant review committees and national breast cancer clinical trial committees. In her role as a clinician and co-leader of the Breast Cancer Research Program at the Sidney Kimmel Cancer Center, she is able to observe current unmet needs in breast cancer screening and treatment and is tasked to find solutions.

Contributions