Paclitaxel

Updated 
August 9, 2019
Reviewed By: 

Paclitaxelinfo-icon (Taxolinfo-icon) is a type of taxaneinfo-icon chemotherapyinfo-icon. Paclitaxel is made from the bark of the Pacific yew tree. It is used to treat breast cancer as well as many other types of cancer.

How Paclitaxel Works

Paclitaxelinfo-icon works by damaging the microtubules, the “skeleton”, that support cancer cells. This stops the cancer cells from dividing normally, and results in the death of the cancer cells.

How Paclitaxel Is Given

Paclitaxelinfo-icon is usually given as part of a regimeninfo-icon with other chemotherapyinfo-icon medicines in early-stageinfo-icon breast cancers that require chemotherapy. A common combination in breast cancer is AC-T (Adriamycin and Cytoxan, followed by Taxol). It can also be given with other chemotherapy medicines like carboplatininfo-icon (Paraplatininfo-icon), or with monoclonal antibodies like trastuzumabinfo-icon (Herceptininfo-icon).

Paclitaxel is given by veininfo-icon. It is usually given in several cycles, with a treatment given on one day, followed by a period of “off” days. The exact schedule depends on the regimen and doseinfo-icon used. It is often given weekly, every 2 weeks, or every 3 weeks.

It can be given as part of neoadjuvant (before surgeryinfo-icon) treatment or as part of adjuvant (after surgery) treatment. An entire course of chemotherapy for breast cancer usually takes from 3 to 6 months.

In some cases your doctor may recommend a dose-dense schedule, which means medicines are given with less time between treatments than in a standard chemotherapy treatment plan. For example, a common treatment regimen is dose-dense doxorubicininfo-icon (Adriamycin) and cyclophosphamideinfo-icon (Cytoxaninfo-icon) every 2 weeks for four cycles followed by paclitaxel (Taxolinfo-icon) every 2 weeks for four cycles.

For metastaticinfo-icon breast cancer, paclitaxel is usually given weekly in low doses, to limit side effects. It can also be given every 3 weeks.

Side Effects and Things to Remember

Before starting paclitaxelinfo-icon, tell your doctor about any medicines you are taking, including vitamins, herbal supplements, and over-the-counterinfo-icon medicines, as well as any existing or previous health problems.

Paclitaxel can cause an allergic reaction, and so can another ingredient given with it, called Cremophor. Your doctor may give you medicineinfo-icon to prevent the reaction on the day that you get treatment.  

Be sure to get emergency medical help if you have any signs of an allergic reaction, such as

  • hives or red skin rash
  • difficulty breathing
  • faintness
  • swelling of your face, lips, tongue, or throat

Other side effects of paclitaxel may include:

Paclitaxel can temporarily affect how your body makes blood cells, which can decrease your blood cellinfo-icon counts. This is called bone marrow suppression. Your doctors will test your blood counts regularly. The blood cell countinfo-icon changes can include a decrease in

  • Red blood cells, which carry oxygen in your body to help give you energy
  • White blood cells, which fight infectioninfo-icon in your body
  • Platelets, which help clot the blood to stop bleeding

Talk to your doctor, pharmacistinfo-icon or nurseinfo-icon about all your side effects so that they can help you manage them. You can also go to our section on Side Effects for more information.

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