FAC: Fluorouracil, Adriamycin and Cytoxan
FAC (Fluorouracil, Adriamycin and Cytoxan
) is a chemotherapy
regimen
sometimes given for localized
breast cancers with a relatively high risk for recurrence
. It is a combination of three chemotherapy medicines:
- Fluorouracil (5-FU) - an antimetabolite
chemotherapy medicine
- Doxorubicin (Adriamycin) - an anthracycline
- Cyclophosphamide (Cytoxan) - an alkylating agent
FAC uses the same medicines as the combination CAF, but has different doses and schedules.
How FAC Works
Each medicine attacks the cancer cells in a different way:
- Fluorouracil
stops cells from making and fixing DNA. This causes the cells to die when they try to divide.
- Doxorubicin
stops DNA production and interferes with the enzymes that repair DNA.
- Cyclophosphamide
stops cancer cells from reproducing.
Who Gets FAC
Doctors typically use FAC to treat HER2-negative breast cancers, regardless of whether the cancer traveld to the lymph nodes. Sometimes, it's used instead of AC chemotherapy.
You and your doctor will discuss the best chemotherapy treatment for your situation.
How is FAC Given
- FAC is usually given in six 3-week cycles.
- All three medicines are given together, by vein
, on the first day of treatment
- Fluorouracil
is given by itself one week later, followed by a 2-week rest period off of all chemotherapy
.
- The entire course of treatment lasts about 18 weeks.
Side Effects and Things to Remember
Different medicines have different side effects. You may not have every side effect related to each medicine
of the combination. Side effects of FAC may include:
- Nausea and vomiting
- Diarrhea
- Mouth sores
- Hair loss
- Heart problems
- Low blood counts (including white blood cells, red blood cells, and platelets)
- Fatigue
- Menopausal symptoms
- Risk of infection
Rare side effects may include increased risk of leukemia, a blood cancer, and heart failure.
Before starting FAC, be sure to tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the-counter medicines, to make sure they won’t interfere with your chemotherapy
treatment.
You should avoid becoming pregnant while you are receiving FAC. Tell your doctor right away if you become pregnant while you are undergoing treatment.
Be sure to talk to your doctor or nurse about all your side effects so that they can help you manage them. You can also go to our section on Side Effects for more information.