Palbociclib (Ibrance), a targeted therapyinfo-icon, is the first CDK 4/6 inhibitor to be approved by the FDAinfo-icon. It targets two specific kinases, or enzymes, that help tumorinfo-icon cells grow and divide.

How Palbociclib Works

Cyclin-dependent kinase 4 and 6 are two enzymes that help tumorinfo-icon cells grow. Palbociclib works by blocking the action of CDK 4 and 6 that signals cancer cells to multiply. This helps slow the growth or spread of cancer cells.

How Palbociclib Is Given

Palbociclib is a pill. It is usually taken with food once a day, at the same time each day, for the first 21 days of a 28-day cycle. You and your doctor will discuss how many times you should repeat this cycle.

Side Effects and Things to Remember

The most common side effects of palbociclib are:

Call your doctor immediately if you have any signs of infection, shortness of breath, chest pain, irregular heartbeat, weakness or unusual bleeding.

Before starting palbociclib, be sure to tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over the counter medicines. Also tell your doctor if you have ever had liver or kidney disease. You should avoid grapefruit and grapefruit juice while you are taking this medicineinfo-icon.

You should avoid becoming pregnant while you are receiving palbociclib and for at least 2 weeks after taking the last doseinfo-icon. Tell your doctor right away if you become pregnant or may be pregnant while you are undergoing treatment.

Your doctor, pharmacistinfo-icon or nurseinfo-icon can help you manage your side effects. You can also go to our section on Side Effects for more information.

August 31, 2015
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