About Us>Medical Advisory Board > Daniel P. Silver, MD, PhD

Daniel P. Silver, MD, PhD

Leader, Breast Program, Sidney Kimmel Cancer Center


  • Leader of the breast cancer program at the Sidney Kimmel Cancer Center at Thomas Jefferson University
  • Developed a biomarker test to predict chemotherapy responsiveness in triple-negative breast cancer

Dr. Silver’s lab focuses on finding new targets for cancer treatment, identifying cancer-related genes and understanding how they work, and developing biomarker tests to predict how well medicines will work in individuals. The lab has also researched the BRCA1 and BRCA2 gene mutations and DNA repair.

Dr. Silver played a significant role in a clinical trial that suggested platinum chemotherapy would be effective in triple-negative breast cancer, and he co-led a project that resulted in a new predictive biomarker test, the HRD Assay, which helps identify when chemotherapy will work well against cancer. Recently, his lab discovered a new cancer-related gene that is amplified and overexpressed in one-third of triple-negative breast cancers and which may be a target for new therapies for this subtype of breast cancer.

Dr. Silver is a member of LBBC's Medical Advisory Board.