FAC: Fluorouracil, Adriamycin and Cytoxan
FAC (Fluorouracil, Adriamycin and Cytoxan) is a chemotherapy regimen sometimes given for localized breast cancers with a relatively high risk for recurrence. It is a combination of three chemotherapy medicines:
- Fluorouracil (5-FU) - an antimetabolite chemotherapy medicine
- Doxorubicin (Adriamycin) - an anthracycline
- Cyclophosphamide (Cytoxan) - an alkylating agent
FAC uses the same medicines as the combination CAF, but has different doses and schedules.
Each medicine attacks the cancer cells in a different way:
Past clinical trials showed FAC to be effective for both node-negative disease (which hasn’t traveled to lymph nodes) and node-positive disease (which has traveled to lymph nodes). It was often used in the past as adjuvant therapy, after and in addition to surgery, for people with locally advanced breast cancer.
You and your doctor will discuss the best chemotherapy treatment for your situation.
- Nausea and vomiting
- Mouth sores
- Hair loss
- Heart problems
- Low blood counts (including white blood cells, red blood cells, and platelets)
- Menopausal symptoms
- Risk of infection
Before starting FAC, be sure to tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the-counter medicines, to make sure they won’t interfere with your chemotherapy treatment.
You should avoid becoming pregnant while you are receiving FAC. Tell your doctor right away if you become pregnant while you are undergoing treatment.