TC: Taxotere and Cyclophosphamide

Updated 
August 31, 2015
Reviewed By: 

TC (Taxotereinfo-icon and Cyclophosphamideinfo-icon) is a common chemotherapyinfo-icon regimeninfo-icon given for localizedinfo-icon breast cancers that require chemotherapy.

It is a combination of two chemotherapy medicines:

Docetaxelinfo-icon is a type of chemotherapy medicineinfo-icon called an taxane.

Cyclophosphamide is a type of chemotherapy medicine called an alkylating agent.

How TC Works

Docetaxelinfo-icon works by damaging the structure or the “skeleton” that supports cancer cells. This stops the cancer cells from growing and dividing.

Cyclophosphamideinfo-icon attaches to and damages the DNA in cancer cells when they are in their resting phase (not dividing). After their DNA is damaged, the cells can’t keep dividing, and their growth slows or stops.

Who Gets TC

TC is one option used to treat people with localizedinfo-icon breast cancer that requires chemotherapyinfo-icon. Unlike some other regimens given for localized breast cancer, TC does not contain an anthracycline. If you have heart health issues, your providers may offer this regimeninfo-icon since anthracyclines like doxorubicininfo-icon (Adriamycin) cannot be given to people with heart problems. 

You and your doctor will discuss the best chemotherapy treatment for your situation.

How TC is Given

TC can be given after surgeryinfo-icon as adjuvant therapyinfo-icon, or before as neoadjuvant therapyinfo-icon.

Both medicines are usually given by veininfo-icon on the same day, followed by a 20-day rest period, making each cycle 3 weeks long. Four cycles are usually given for a total treatment period of 3 months on average.

Side Effects and Things to Remember

Different medicines have different side effects. You may not have every side effectinfo-icon related to each medicineinfo-icon of the combination therapyinfo-icon.

Common side effects of TC include:

Less common side effects include:

Before starting TC, tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the-counterinfo-icon medicines, to make sure they won’t interfere with your chemotherapyinfo-icon treatment.

You should avoid becoming pregnant while you are receiving TC. Tell your doctor right away if you become pregnant while you are undergoing treatment.

Talk to your doctor, pharmacistinfo-icon or nurseinfo-icon about all your side effects so that they can help you manage them. You can also go to our section on Side Effects for more information.

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