TCH: Taxotere, Carboplatin and Herceptin
- Docetaxel (Taxotere)or paclitaxel (Taxol), taxane chemotherapy medicines
- Carboplatin (Paraplatin), a platinum-type chemotherapy
And a targeted therapy:
Docetaxel and paclitaxel work by damaging the structure or the “skeleton” that supports cancer cells. This stops the cancer cells from growing and dividing. Carboplatin stops cancer cells from reproducing by sticking to their DNA.
Trastuzumab (H) attaches to HER2 proteins on the surface of HER2-positive cancer cells, and blocks the signals that cause the cancer cells to multiply.
- HER2-positive and node-positive, when the cancer has traveled to lymph nodes
- HER2-positive, node-negative, when the cancer hasn’t traveled to lymph nodes
You and your doctor will discuss the best chemotherapy treatment for your situation.
You will probably have 4 to 6 treatments of paclitaxel or docetaxel, and carboplatin every 3 weeks. You may also get treated on a weekly basis. Trastuzumab is then given weekly or every 3 weeks for a total of a year.
- Nausea and vomiting
- Hair loss
- Risk of infection
- Mouth sores
- Joint pain
- Nail changes
- Neuropathy, numbness or tingling in the hands or feet
- Heart issues
Before starting TCH, tell your doctor about any medicines you are taking, including vitamins, herbal supplements and over-the-counter medicines, to make sure they won’t interfere with your chemotherapy treatment.
Trastuzumab can cause complications in pregnancy, so you should not become pregnant while taking it.